AustralieFrV1, Main, Exploration, bibRecord, 002197

Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions

Identifieur interne : 002197 ( Main/Exploration ); précédent : 002196; suivant : 002198

Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions

Auteurs : Rajat Kumar [Canada] ; Fumihiko Kimura [Japon] ; Kwang Woo Ahn [États-Unis] ; Zhen-Huan Hu [États-Unis] ; Yachiyo Kuwatsuka [États-Unis, Japon] ; John P. Klein [États-Unis] ; Marcelo Pasquini [États-Unis] ; Koichi Miyamura [Japon] ; Koji Kato [Japon] ; Ayami Yoshimi [Allemagne] ; Yoshihiro Inamoto [Japon] ; Tatsuo Ichinohe [Japon] ; William Allen Wood [États-Unis] ; Baldeep Wirk [États-Unis] ; Matthew Seftel [Canada] ; Philip Rowlings [Australie] ; David I. Marks [Royaume-Uni] ; Kirk R. Schultz [Canada] ; Vikas Gupta [Canada] ; Laurence Dedeken [Belgique] ; Biju George [Inde] ; Jean-Yves Cahn [France] ; Jeff Szer [Australie] ; Jong Wook Lee [Corée du Sud] ; Aloysius Yl Ho [Singapour] ; Anders Fasth [Suède] ; Theresa Hahn [États-Unis] ; Nandita Khera [États-Unis] ; Jignesh Dalal [États-Unis] ; Carmem Bonfim [Brésil] ; Mahmoud Aljurf [Arabie saoudite] ; Yoshiko Atsuta [Japon] ; Wael Saber [États-Unis]

Source :

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1083-8791 ] ; 2016.

RBID : PMC:4826285

Descripteurs français

English descriptors

KwdEn :
- Adolescent, Adult, Aged, Anemia, Aplastic (mortality), Anemia, Aplastic (therapy), Bone Marrow Transplantation, Child, Child, Preschool, Female, Follow-Up Studies, Graft Rejection (mortality), Humans, Infant, Japan, Male, Middle Aged, Peripheral Blood Stem Cell Transplantation, Retrospective Studies, Siblings, Socioeconomic Factors.
MESH :
- mortality : Anemia, Aplastic, Graft Rejection.
- therapy : Anemia, Aplastic.
- Adolescent, Adult, Aged, Bone Marrow Transplantation, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Japan, Male, Middle Aged, Peripheral Blood Stem Cell Transplantation, Retrospective Studies, Siblings, Socioeconomic Factors.

Abstract

Bone marrow (BM) is the preferred graft source for hematopoietic stem cell transplantation (HSCT) in severe aplastic anemia (SAA) compared to mobilized peripheral blood stem cells (PBSC). We hypothesized that this recommendation may not apply to those regions where patients present later in their disease course, with heavier transfusion load and with higher graft failure rates. Patients with SAA who received HSCT from an HLA-matched sibling donor from 1995 to 2009 and reported to the Center for International Blood and Marrow Transplant Research or the Japan Society for Hematopoietic Cell Transplantation were analyzed. The study population was categorized by gross national income per capita (GNI) and region/countries into four groups. Groups analyzed were high income countries (HIC), which were further divided into US-Canada (N=486) and other HIC (N=1264), upper middle-income (UMIC) (N=482), and combined lower middle, low income countries (LM-LIC) (N=142). In multivariate analysis, overall survival (OS) was highest with BM as graft source in HIC compared to PBSC in all countries or BM in UMIC or LM-LIC (p<0.001). There was no significant difference in OS between BM and PBSC in UMIC (p=0.32) or LM-LIC (p=0.23). In LM-LIC the 28-day neutrophil engraftment was higher with PBSC compared to BM (97% vs. 77%, p<0.001). Chronic GVHD was significantly higher with PBSC in all groups. Whereas BM should definitely be the preferred graft source for HLA-matched sibling HSCT in SAA, PBSC may be an acceptable alternative in countries with limited resources when treating patients at high risk of graft failure and infective complications.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826285

DOI: 10.1016/j.bbmt.2016.01.012
PubMed: 26797402
PubMed Central: 4826285

Affiliations:

Le document en format XML

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<author><name sortKey="Dedeken, Laurence" sort="Dedeken, Laurence" uniqKey="Dedeken L" first="Laurence" last="Dedeken">Laurence Dedeken</name>
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<author><name sortKey="George, Biju" sort="George, Biju" uniqKey="George B" first="Biju" last="George">Biju George</name>
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<author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
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<author><name sortKey="Szer, Jeff" sort="Szer, Jeff" uniqKey="Szer J" first="Jeff" last="Szer">Jeff Szer</name>
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<author><name sortKey="Lee, Jong Wook" sort="Lee, Jong Wook" uniqKey="Lee J" first="Jong Wook" last="Lee">Jong Wook Lee</name>
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<author><name sortKey="Fasth, Anders" sort="Fasth, Anders" uniqKey="Fasth A" first="Anders" last="Fasth">Anders Fasth</name>
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<author><name sortKey="Hahn, Theresa" sort="Hahn, Theresa" uniqKey="Hahn T" first="Theresa" last="Hahn">Theresa Hahn</name>
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<author><name sortKey="Khera, Nandita" sort="Khera, Nandita" uniqKey="Khera N" first="Nandita" last="Khera">Nandita Khera</name>
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<placeName><region type="state">Arizona</region>
</placeName>
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</author>
<author><name sortKey="Dalal, Jignesh" sort="Dalal, Jignesh" uniqKey="Dalal J" first="Jignesh" last="Dalal">Jignesh Dalal</name>
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<author><name sortKey="Bonfim, Carmem" sort="Bonfim, Carmem" uniqKey="Bonfim C" first="Carmem" last="Bonfim">Carmem Bonfim</name>
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<author><name sortKey="Atsuta, Yoshiko" sort="Atsuta, Yoshiko" uniqKey="Atsuta Y" first="Yoshiko" last="Atsuta">Yoshiko Atsuta</name>
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<affiliation wicri:level="1"><nlm:aff id="A29">Nagoya University Graduate School of Medicine, Nagoya, Japan</nlm:aff>
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<wicri:noRegion>Nagoya</wicri:noRegion>
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<author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
<affiliation wicri:level="2"><nlm:aff id="A3">CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
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</affiliation>
</author>
<author><name sortKey="Kimura, Fumihiko" sort="Kimura, Fumihiko" uniqKey="Kimura F" first="Fumihiko" last="Kimura">Fumihiko Kimura</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Division of Hematology, National Defense Medical College, Tokorozawa, Japan</nlm:aff>
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<wicri:regionArea>Division of Hematology, National Defense Medical College, Tokorozawa</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hu, Zhen Huan" sort="Hu, Zhen Huan" uniqKey="Hu Z" first="Zhen-Huan" last="Hu">Zhen-Huan Hu</name>
<affiliation wicri:level="2"><nlm:aff id="A3">CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kuwatsuka, Yachiyo" sort="Kuwatsuka, Yachiyo" uniqKey="Kuwatsuka Y" first="Yachiyo" last="Kuwatsuka">Yachiyo Kuwatsuka</name>
<affiliation wicri:level="2"><nlm:aff id="A3">CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan</nlm:aff>
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<wicri:regionArea>Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Klein, John P" sort="Klein, John P" uniqKey="Klein J" first="John P." last="Klein">John P. Klein</name>
<affiliation wicri:level="2"><nlm:aff id="A3">CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Pasquini, Marcelo" sort="Pasquini, Marcelo" uniqKey="Pasquini M" first="Marcelo" last="Pasquini">Marcelo Pasquini</name>
<affiliation wicri:level="2"><nlm:aff id="A3">CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee, WI</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Miyamura, Koichi" sort="Miyamura, Koichi" uniqKey="Miyamura K" first="Koichi" last="Miyamura">Koichi Miyamura</name>
<affiliation wicri:level="1"><nlm:aff id="A5">Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Kato, Koji" sort="Kato, Koji" uniqKey="Kato K" first="Koji" last="Kato">Koji Kato</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Department of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Yoshimi, Ayami" sort="Yoshimi, Ayami" uniqKey="Yoshimi A" first="Ayami" last="Yoshimi">Ayami Yoshimi</name>
<affiliation wicri:level="3"><nlm:aff id="A7">Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name>
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<wicri:regionArea>Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ichinohe, Tatsuo" sort="Ichinohe, Tatsuo" uniqKey="Ichinohe T" first="Tatsuo" last="Ichinohe">Tatsuo Ichinohe</name>
<affiliation wicri:level="1"><nlm:aff id="A9">Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima</wicri:regionArea>
<wicri:noRegion>Hiroshima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wood, William Allen" sort="Wood, William Allen" uniqKey="Wood W" first="William Allen" last="Wood">William Allen Wood</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, NC</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Division of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name>
<affiliation wicri:level="4"><nlm:aff id="A1">CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>CancerCare Manitoba, University of Manitoba, Winnipeg, MB</wicri:regionArea>
<orgName type="university">Université du Manitoba</orgName>
<placeName><settlement type="city">Winnipeg</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Rowlings, Philip" sort="Rowlings, Philip" uniqKey="Rowlings P" first="Philip" last="Rowlings">Philip Rowlings</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>Calvary Mater Newcastle, HAPS-Pathology North, University of Newcastle</wicri:regionArea>
<wicri:noRegion>University of Newcastle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I" last="Marks">David I. Marks</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Pediatric Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Pediatric Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Schultz, Kirk R" sort="Schultz, Kirk R" uniqKey="Schultz K" first="Kirk R." last="Schultz">Kirk R. Schultz</name>
<affiliation wicri:level="1"><nlm:aff id="A14">BC Children's Hospital and Child and Family Research Institute, Vancouver, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>BC Children's Hospital and Child and Family Research Institute, Vancouver</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre. Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre. Toronto, Ontario</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Dedeken, Laurence" sort="Dedeken, Laurence" uniqKey="Dedeken L" first="Laurence" last="Dedeken">Laurence Dedeken</name>
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<country xml:lang="fr">Belgique</country>
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</placeName>
</affiliation>
</author>
<author><name sortKey="George, Biju" sort="George, Biju" uniqKey="George B" first="Biju" last="George">Biju George</name>
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<country xml:lang="fr">Inde</country>
<wicri:regionArea>Christian Medical College, Vellore</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Hematology, University Hospital, Grenoble</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Szer, Jeff" sort="Szer, Jeff" uniqKey="Szer J" first="Jeff" last="Szer">Jeff Szer</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Department Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Jong Wook" sort="Lee, Jong Wook" uniqKey="Lee J" first="Jong Wook" last="Lee">Jong Wook Lee</name>
<affiliation wicri:level="3"><nlm:aff id="A20">BMT Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>BMT Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ho, Aloysius Yl" sort="Ho, Aloysius Yl" uniqKey="Ho A" first="Aloysius Yl" last="Ho">Aloysius Yl Ho</name>
<affiliation wicri:level="1"><nlm:aff id="A21">Singapore General Hospital, Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore General Hospital, Singapore</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Fasth, Anders" sort="Fasth, Anders" uniqKey="Fasth A" first="Anders" last="Fasth">Anders Fasth</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Pediatrics, University of Gothenburg, Gothenburg</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Hahn, Theresa" sort="Hahn, Theresa" uniqKey="Hahn T" first="Theresa" last="Hahn">Theresa Hahn</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Roswell Park Cancer Institute, Buffalo, NY</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Roswell Park Cancer Institute, Buffalo</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Khera, Nandita" sort="Khera, Nandita" uniqKey="Khera N" first="Nandita" last="Khera">Nandita Khera</name>
<affiliation wicri:level="2"><nlm:aff id="A24">Department of Hematology/Oncology, Mayo Clinic, Phoenix, AZ</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Arizona</region>
</placeName>
<wicri:cityArea>Department of Hematology/Oncology, Mayo Clinic, Phoenix</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Dalal, Jignesh" sort="Dalal, Jignesh" uniqKey="Dalal J" first="Jignesh" last="Dalal">Jignesh Dalal</name>
<affiliation wicri:level="2"><nlm:aff id="A25">Rainbow Babies& Children's Hospital/Case Western Reserve University, Cleveland, OH</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Ohio</region>
</placeName>
<wicri:cityArea>Rainbow Babies& Children's Hospital/Case Western Reserve University, Cleveland</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bonfim, Carmem" sort="Bonfim, Carmem" uniqKey="Bonfim C" first="Carmem" last="Bonfim">Carmem Bonfim</name>
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<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Hospital de Clinicas - Federal University of Parana, Curitiba</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Aljurf, Mahmoud" sort="Aljurf, Mahmoud" uniqKey="Aljurf M" first="Mahmoud" last="Aljurf">Mahmoud Aljurf</name>
<affiliation wicri:level="1"><nlm:aff id="A27">Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Atsuta, Yoshiko" sort="Atsuta, Yoshiko" uniqKey="Atsuta Y" first="Yoshiko" last="Atsuta">Yoshiko Atsuta</name>
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<country xml:lang="fr">Japon</country>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A29">Nagoya University Graduate School of Medicine, Nagoya, Japan</nlm:aff>
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</author>
<author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Wisconsin</region>
</placeName>
<wicri:cityArea>CIBMTR (Center for International Blood and Marrow Transplant Research), Department of Medicine, Medical College of Wisconsin, Milwaukee</wicri:cityArea>
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</author>
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<series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title>
<idno type="ISSN">1083-8791</idno>
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<imprint><date when="2016">2016</date>
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<front><div type="abstract" xml:lang="en"><p id="P1">Bone marrow (BM) is the preferred graft source for hematopoietic stem cell transplantation (HSCT) in severe aplastic anemia (SAA) compared to mobilized peripheral blood stem cells (PBSC). We hypothesized that this recommendation may not apply to those regions where patients present later in their disease course, with heavier transfusion load and with higher graft failure rates. Patients with SAA who received HSCT from an HLA-matched sibling donor from 1995 to 2009 and reported to the Center for International Blood and Marrow Transplant Research or the Japan Society for Hematopoietic Cell Transplantation were analyzed. The study population was categorized by gross national income per capita (GNI) and region/countries into four groups. Groups analyzed were high income countries (HIC), which were further divided into US-Canada (N=486) and other HIC (N=1264), upper middle-income (UMIC) (N=482), and combined lower middle, low income countries (LM-LIC) (N=142). In multivariate analysis, overall survival (OS) was highest with BM as graft source in HIC compared to PBSC in all countries or BM in UMIC or LM-LIC (p<0.001). There was no significant difference in OS between BM and PBSC in UMIC (p=0.32) or LM-LIC (p=0.23). In LM-LIC the 28-day neutrophil engraftment was higher with PBSC compared to BM (97% vs. 77%, p<0.001). Chronic GVHD was significantly higher with PBSC in all groups. Whereas BM should definitely be the preferred graft source for HLA-matched sibling HSCT in SAA, PBSC may be an acceptable alternative in countries with limited resources when treating patients at high risk of graft failure and infective complications.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Arabie saoudite</li>
<li>Australie</li>
<li>Belgique</li>
<li>Brésil</li>
<li>Canada</li>
<li>Corée du Sud</li>
<li>France</li>
<li>Inde</li>
<li>Japon</li>
<li>Royaume-Uni</li>
<li>Singapour</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Arizona</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Bade-Wurtemberg</li>
<li>Caroline du Nord</li>
<li>District de Fribourg-en-Brisgau</li>
<li>Manitoba</li>
<li>Ohio</li>
<li>Rhône-Alpes</li>
<li>Région capitale de Séoul</li>
<li>Région de Bruxelles-Capitale</li>
<li>Région de Kantō</li>
<li>Washington (État)</li>
<li>Wisconsin</li>
<li>État de New York</li>
</region>
<settlement><li>Bruxelles</li>
<li>Fribourg-en-Brisgau</li>
<li>Grenoble</li>
<li>Séoul</li>
<li>Tokyo</li>
<li>Winnipeg</li>
</settlement>
<orgName><li>Université du Manitoba</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Manitoba"><name sortKey="Kumar, Rajat" sort="Kumar, Rajat" uniqKey="Kumar R" first="Rajat" last="Kumar">Rajat Kumar</name>
</region>
<name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name>
<name sortKey="Schultz, Kirk R" sort="Schultz, Kirk R" uniqKey="Schultz K" first="Kirk R." last="Schultz">Kirk R. Schultz</name>
<name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name>
</country>
<country name="Japon"><noRegion><name sortKey="Kimura, Fumihiko" sort="Kimura, Fumihiko" uniqKey="Kimura F" first="Fumihiko" last="Kimura">Fumihiko Kimura</name>
</noRegion>
<name sortKey="Atsuta, Yoshiko" sort="Atsuta, Yoshiko" uniqKey="Atsuta Y" first="Yoshiko" last="Atsuta">Yoshiko Atsuta</name>
<name sortKey="Atsuta, Yoshiko" sort="Atsuta, Yoshiko" uniqKey="Atsuta Y" first="Yoshiko" last="Atsuta">Yoshiko Atsuta</name>
<name sortKey="Ichinohe, Tatsuo" sort="Ichinohe, Tatsuo" uniqKey="Ichinohe T" first="Tatsuo" last="Ichinohe">Tatsuo Ichinohe</name>
<name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name>
<name sortKey="Kato, Koji" sort="Kato, Koji" uniqKey="Kato K" first="Koji" last="Kato">Koji Kato</name>
<name sortKey="Kuwatsuka, Yachiyo" sort="Kuwatsuka, Yachiyo" uniqKey="Kuwatsuka Y" first="Yachiyo" last="Kuwatsuka">Yachiyo Kuwatsuka</name>
<name sortKey="Miyamura, Koichi" sort="Miyamura, Koichi" uniqKey="Miyamura K" first="Koichi" last="Miyamura">Koichi Miyamura</name>
</country>
<country name="États-Unis"><region name="Wisconsin"><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name>
</region>
<name sortKey="Dalal, Jignesh" sort="Dalal, Jignesh" uniqKey="Dalal J" first="Jignesh" last="Dalal">Jignesh Dalal</name>
<name sortKey="Hahn, Theresa" sort="Hahn, Theresa" uniqKey="Hahn T" first="Theresa" last="Hahn">Theresa Hahn</name>
<name sortKey="Hu, Zhen Huan" sort="Hu, Zhen Huan" uniqKey="Hu Z" first="Zhen-Huan" last="Hu">Zhen-Huan Hu</name>
<name sortKey="Khera, Nandita" sort="Khera, Nandita" uniqKey="Khera N" first="Nandita" last="Khera">Nandita Khera</name>
<name sortKey="Klein, John P" sort="Klein, John P" uniqKey="Klein J" first="John P." last="Klein">John P. Klein</name>
<name sortKey="Kuwatsuka, Yachiyo" sort="Kuwatsuka, Yachiyo" uniqKey="Kuwatsuka Y" first="Yachiyo" last="Kuwatsuka">Yachiyo Kuwatsuka</name>
<name sortKey="Pasquini, Marcelo" sort="Pasquini, Marcelo" uniqKey="Pasquini M" first="Marcelo" last="Pasquini">Marcelo Pasquini</name>
<name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name>
<name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name>
<name sortKey="Wood, William Allen" sort="Wood, William Allen" uniqKey="Wood W" first="William Allen" last="Wood">William Allen Wood</name>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Yoshimi, Ayami" sort="Yoshimi, Ayami" uniqKey="Yoshimi A" first="Ayami" last="Yoshimi">Ayami Yoshimi</name>
</region>
</country>
<country name="Australie"><noRegion><name sortKey="Rowlings, Philip" sort="Rowlings, Philip" uniqKey="Rowlings P" first="Philip" last="Rowlings">Philip Rowlings</name>
</noRegion>
<name sortKey="Szer, Jeff" sort="Szer, Jeff" uniqKey="Szer J" first="Jeff" last="Szer">Jeff Szer</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I" last="Marks">David I. Marks</name>
</noRegion>
</country>
<country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Dedeken, Laurence" sort="Dedeken, Laurence" uniqKey="Dedeken L" first="Laurence" last="Dedeken">Laurence Dedeken</name>
</region>
</country>
<country name="Inde"><noRegion><name sortKey="George, Biju" sort="George, Biju" uniqKey="George B" first="Biju" last="George">Biju George</name>
</noRegion>
</country>
<country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name>
</region>
</country>
<country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Lee, Jong Wook" sort="Lee, Jong Wook" uniqKey="Lee J" first="Jong Wook" last="Lee">Jong Wook Lee</name>
</region>
</country>
<country name="Singapour"><noRegion><name sortKey="Ho, Aloysius Yl" sort="Ho, Aloysius Yl" uniqKey="Ho A" first="Aloysius Yl" last="Ho">Aloysius Yl Ho</name>
</noRegion>
</country>
<country name="Suède"><noRegion><name sortKey="Fasth, Anders" sort="Fasth, Anders" uniqKey="Fasth A" first="Anders" last="Fasth">Anders Fasth</name>
</noRegion>
</country>
<country name="Brésil"><noRegion><name sortKey="Bonfim, Carmem" sort="Bonfim, Carmem" uniqKey="Bonfim C" first="Carmem" last="Bonfim">Carmem Bonfim</name>
</noRegion>
</country>
<country name="Arabie saoudite"><noRegion><name sortKey="Aljurf, Mahmoud" sort="Aljurf, Mahmoud" uniqKey="Aljurf M" first="Mahmoud" last="Aljurf">Mahmoud Aljurf</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions

Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions

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